Ampicillin Sodium Injectable, a broad-spectrum β-lactam antibiotic, inhibits bacterial cell wall synthesis to target both Gram-positive and negative bacteria, available in 0.5g/1g/2g vials. Indications include respiratory infections (2-6g daily IV for adults), typhoid (2-6g daily ×2 weeks), and endocarditis (12g daily with aminoglycosides), but it's resistant to β-lactamase-producing strains. Key risks are allergic reactions (rash, anaphylaxis) and GI issues; mandatory penicillin skin testing is required. Stored dry and sealed, it's reconstituted before use, with dosage adjusted in renal impairment. As a pregnancy category B drug, it balances efficacy against resistance by requiring culture-guided use, often replaced by enzyme-inhibitor combos in clinical practice due to emerging resistance.
Ampicillin Sodium Injectable Introduction
1. Basic Drug Information
Item
Details
Generic Name
Ampicillin Sodium Injectable
Drug Class
β-lactam antibiotic (broad-spectrum penicillin)
Mechanism of Action
Inhibits bacterial cell wall synthesis, active against both Gram-positive and Gram-negative bacteria
Common Specifications
0.5g/vial, 1g/vial, 2g/vial (calculated as ampicillin)
Suitable for pneumonia, acute bronchitis; adjust based on pathogens.
Urogenital infections
Adults: 2-4g daily, IM/IV divided 4 times.
Effective against E. coli-induced urethritis, pyelonephritis.
Typhoid & other salmonella infections
Adults: 2-6g daily, IV divided 3-4 times (2-week course);
Children: 100-200mg/kg daily.
Traditional first-line for typhoid (pending drug sensitivity).
Endocarditis
Adults: 12g daily, IV divided 6 times, combined with aminoglycosides for 4-6 weeks.
Guided by blood culture; monitor serum drug levels.
3. Pharmacological Properties
Antibacterial Spectrum:
Sensitive pathogens: Streptococcus pyogenes, Streptococcus pneumoniae, non-resistant staphylococci, Haemophilus influenzae, E. coli (some strains), Salmonella, Shigella, etc.
Drug resistance: Resistant to β-lactamase-producing bacteria (e.g., MRSA, most Enterobacteriaceae); combine with β-lactamase inhibitors (e.g., ampicillin-sulbactam) for resistance.
Pharmacokinetics:
Rapid peak concentration after IV administration; crosses placenta and enters cerebrospinal fluid (during meningitis); excreted mainly by kidneys (dose adjustment needed in renal impairment).
4. Adverse Reactions & Contraindications
Major Side Effects:
Allergic reactions: Rash (most common), pruritus, urticaria; anaphylactic shock in severe cases;
Gastrointestinal reactions: Nausea, vomiting, diarrhea; prolonged use may cause superinfection (e.g., pseudomembranous colitis);
Resistant bacterial infections in respiratory/soft tissues
Piperacillin-tazobactam
Potent against Pseudomonas aeruginosa
Severe/hospital-acquired infections
7. Storage & Management
Storage: Store in a dry place, tightly sealed; reconstitute powder with sterile water for injection immediately before use.
Regulation: Prescription-only drug; prepare IV solution fresh (efficacy decreases and allergenicity increases with storage).
Resistance Control: Avoid empiric use; guide therapy with culture and sensitivity testing to delay resistance.
Company Introduce
Related Products
RFQ Q: Are you a manufacturer? A: Yes, we have established our own factory since 2002, with the latest GMP certification, independent R&D center, and advanced production equipment. The group has been listed as a reputable brand by CCTV. We can strictly control product quality to ensure you can buy high-quality, cost-effective products.
Q: What products can you provide? A: We have multiple production lines for powders, injections, premixes, oral liquids, and biological additives, we are leaders in the production of veterinary drugs, animal feed, feed additives, pharmaceutical intermediates, pharmaceutical raw materials. Our diverse range of products includes offerings for pets, poultry, cattle, sheep, pigs, and aquatic species.
Q: Do you test all your goods before delivery? A: Yes, we conduct 100% testing before delivery to ensure that each batch of veterinary drugs undergoes strict quality testing, and if you require, we warmly welcome third-party testing with international authorization for our products.
Q: Can we have the sample? A: Of course, you can place a sample order first to test the company's quality and service. For some products, we can provide free samples.
Q: What is the MOQ (minimum order quantity)? A: We have a significant advantage in MOQ because we offer small MOQ. 100 bottles of injection and 1kg of powder.
Q: Can I use my own design package? A: Yes, OEM service is available. We can customize packaging and labels to create a unique brand for dealers. In addition, we can also customize specifications and formulas according to different requirements.
Q: How about delivery time? A: We have ample inventory and are ready to ship. Most of our factory orders are normally shipped within 3-5 days upon receiving your payment.
Q: Do you provide after sales service? A: We have a clear division of work and offer after-sales service within 8 hours. If there are any quality problems, we will be responsible to the end.
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