Ivermectin is a valuable tool in veterinary parasitology but requires careful administration based on species, breed, and parasite type. Its safety profile is generally good when used as directed, but vigilance is essential to prevent adverse effects, particularly in genetically sensitive animals.
1. Mechanism of Action
Ivermectin works by binding to glutamate-gated chloride channels in the nervous system of parasites, causing increased chloride ion permeability. This leads to paralytic death of the parasite.
It is highly effective against adult and larval stages of many parasites but may not kill eggs (requires repeated dosing in some cases).
2. Veterinary Indications
Ivermectin is approved for various species, but off-label use may occur under veterinary supervision. Key uses include:
Off-label use for mites (e.g., red mites in chickens).
Dermanyssus gallinae
Note: In dogs, ivermectin is the primary drug for heartworm prevention . Injectable forms are less common in small animals but may be used for severe mange.
3. Administration and Dosage
Route of Administration:
Injectable Form: Given subcutaneously (SC) or intramuscularly (IM), depending on the species and product label.
Oral Form: More common in small animals (pills, chewables) or large animals (pastes, drenches).
Topical Form: Spot-on solutions for cats/dogs (e.g., for fleas and mites).
Repeat dosing may be required for egg-rich infections (e.g., every 2-4 weeks) or chronic infestations (e.g., mange).
4. Safety and Precautions
Species Sensitivity:
Collie and Herding Breeds (e.g., Collies, Shelties): These breeds may have a MDR1 gene mutation (multidrug resistance protein) that causes ivermectin to accumulate in the brain, leading to neurotoxicity (tremors, ataxia, coma, death). Avoid injectable ivermectin in these breeds unless specifically formulated for low doses (e.g., heartworm preventives at approved doses are safe).
Cats: Highly sensitive to ivermectin overdose. Injectable forms are rarely used; topical formulations are preferred at precise doses.
Horses: Generally safe at recommended doses, but avoid in foals under 3 months (risk of colic).
Adverse Effects:
Mild Reactions: Transient swelling/pain at injection site, diarrhea, lethargy, vomiting (rare in most species).
Severe Reactions (overdose or sensitivity):
Neurological signs: Ataxia, tremors, seizures, coma (more common in Collies or with high doses).
Hypersensitivity reactions: Rare but may include facial swelling or anaphylaxis.
Contraindications:
Do not use in pregnant animals unless the benefit outweighs risk (some products are labeled safe in late pregnancy; check labeling).
Avoid in weak, sick, or dehydrated animals (may increase risk of adverse effects).
Withdrawal Periods (for food-producing animals):
Cattle/sheep: Withdrawal period for meat is typically 28-45 days; for milk, 9 days (varies by product).
Swine: Withdrawal period for meat is ~28 days.
Always follow local regulations and product labels to avoid drug residues in food.
Other Antiparasitics: Avoid combining with other neuroactive drugs (e.g., organophosphates) due to additive toxicity potential.
6. Storage and Handling
Store injectable ivermectin in a cool, dark place (2-8°C for refrigerated products; check label).
Keep out of reach of children and pets.
Dispose of unused medication properly (do not contaminate water sources).
7. Alternatives and Off-Label Use
Alternatives for MDR1-Sensitive Breeds:
Milbemycin oxime or selamectin for heartworm prevention in dogs.
Topical spot-on products (e.g., fipronil, imidacloprid) for ectoparasites.
Off-Label Use:
In reptiles or exotic animals (e.g., for mites), but dosage must be carefully calculated by a veterinarian experienced in exotic species.
Company Introduce
Related Products
RFQ Q: Are you a manufacturer? A: Yes, we have established our own factory since 2002, with the latest GMP certification, independent R&D center, and advanced production equipment. The group has been listed as a reputable brand by CCTV. We can strictly control product quality to ensure you can buy high-quality, cost-effective products.
Q: What products can you provide? A: We have multiple production lines for powders, injections, premixes, oral liquids, and biological additives, we are leaders in the production of veterinary drugs, animal feed, feed additives, pharmaceutical intermediates, pharmaceutical raw materials. Our diverse range of products includes offerings for pets, poultry, cattle, sheep, pigs, and aquatic species.
Q: Do you test all your goods before delivery? A: Yes, we conduct 100% testing before delivery to ensure that each batch of veterinary drugs undergoes strict quality testing, and if you require, we warmly welcome third-party testing with international authorization for our products.
Q: Can we have the sample? A: Of course, you can place a sample order first to test the company's quality and service. For some products, we can provide free samples.
Q: What is the MOQ (minimum order quantity)? A: We have a significant advantage in MOQ because we offer small MOQ. 100 bottles of injection and 1kg of powder.
Q: Can I use my own design package? A: Yes, OEM service is available. We can customize packaging and labels to create a unique brand for dealers. In addition, we can also customize specifications and formulas according to different requirements.
Q: How about delivery time? A: We have ample inventory and are ready to ship. Most of our factory orders are normally shipped within 3-5 days upon receiving your payment.
Q: Do you provide after sales service? A: We have a clear division of work and offer after-sales service within 8 hours. If there are any quality problems, we will be responsible to the end.
Audited Supplier 
){kind=link}