Indomethacin Capsules contain indomethacin as the active ingredient and belong to the class of nonsteroidal anti-inflammatory drugs (NSAIDs). They possess anti-inflammatory, analgesic, and antipyretic properties, and are indicated for relieving inflammation associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis, as well as for managing postoperative or traumatic pain and fever.
Product Description
Indications:
The treatment of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute musculoskeletal disorders and acute gout.
Contra-indications:
Active peptic ulcer or a history of recurrent gastro-intestinal lesions. Sensitivity to aspirin, indometacin or other non-steroidal anti-inflammatory agents.
Pregnancy or lactation.
Patients operating machinery.
Patients with epilepsy, parkinsonism, psychiatric disturbances or porphyria.
Children, since conditions for safe use have not been established.
Severe heart failure.
Adverse Effects:
Most adverse effects are dose related
Gastro-intestinal adverse effects are common and include anorexia, nausea (with or without vomiting) dyspepsia, abdominal pain and diarrhoea. Infrequently, ulceration of the upper GI tract, sometimes with perforation and haemorrhage, has occurred. Acute pancreatitis has been reported. Hepatic involvement is rare, though fatal cases of hepatitis and jaundice have been reported.
CNS effects are also common. Severe frontal headache may occur in 25 - 50% of patients who take the drug chronically. Dizziness, light-headedness, vertigo and mental confusion are also frequent. Depression and psychosis have also been reported but the incidence is less than 1%.
Haemopoietic reactions, including neutropenia, thrombocytopenia and, rarely, aplastic anaemia have been reported.
Hypersensitivity reactions, manifested as rashes, itching, urticaria or rarely acute asthma, may occur.
Oedema, hypertension, and cardiac failure, have been reported in association with NSAID treatment.
Drug Interactions:
1.Probenecid. The plasma concentration of Indometacin is increased.
2.Frusemide. The natriuretic and anti-hypersensitivity effects are antagonised by Indometacin.
3.Thiazide diuretics and beta-blocking agents. Indometacin reduces the anti-hypertensive effects of these compounds.
4.Antacids. The bioavailability of Indometacin may be reduced by concomitant antacid therapy.
5.Triamterene. Acute renal failure has been reported with concomitant Indometacin therapy.
Precautions & Warning:
Indometacin should be used with great care in elderly patients. Indometacin should be used with caution in patients with impaired renal function. Indometacin inhibits platelet aggregation and prolongs bleeding time. It should be used with caution therefore in patients with bleeding disorders, and concurrent administration of anti-coagulant agent may be hazardous because of increased risk of gastrointestinal bleeding.
Peptic ulcer has been reported in a small proportion of patients. If G.I. bleeding occurs, indometacin should be discontinued immediately. Indometacin may mask the signs and symptoms of infection. If clinical signs of hepatic disease develop, or if liver function tests become abnormal, indometacin should be withdrawn. Indometacin should be given with or immediately after food in order to lessen the incidence and severity of gastrointestinal side-effects.
Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms (see section 4.2, and GI and cardiovascular risks below).
Use in Pregnancy and Nursing Mothers:
Indometacin is contraindicated during pregnancy and lactation.
Treatment/antidote in The Event of Overdose:
Gastric lavage should be performed if ingestion is recent. Otherwise, supportive measures and observation.
Storage instructions:
Store below 25ºC. Protect from moisture. Keep out of reach of children.
Company Introduce
S.Silom Medical Co., Ltd. is a professional medical and pharmaceutical products supplier in China. We have been focused on exporting medicines, APIs, and medical products, accumulating a wealth of experience. Our products have been exported mainly in Asia, Africa, South America, Middle East and Europe, such as Philippines, Cambodia, Kyrghyzstan, Cameroon, Guinea, Nigeria, Liberia, Mali, Yemen, Turkey, Bolivia, Chile, and so on.
To supply sustainable, high quality products, competitive price and satisfactory service is our mission. We won high recognition in the international market by professional product knowledge, efficient supply chain management and excellent service, establishing extensive and mature distribution channels in international market.
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RFQ
Q: Are you a manufacturer?
A: Yes, we have established our own factory since 2002, with the latest GMP certification, independent R&D center, and advanced production equipment. The group has been listed as a reputable brand by CCTV. We can strictly control product quality to ensure you can buy high-quality, cost-effective products.
Q: What products can you provide?
A: We have multiple production lines for powders, injections, premixes, oral liquids, and biological additives, we are leaders in the production of veterinary drugs, animal feed, feed additives, pharmaceutical intermediates, pharmaceutical raw materials. Our diverse range of products includes offerings for pets, poultry, cattle, sheep, pigs, and aquatic species.
Q: Do you test all your goods before delivery?
A: Yes, we conduct 100% testing before delivery to ensure that each batch of veterinary drugs undergoes strict quality testing, and if you require, we warmly welcome third-party testing with international authorization for our products.
Q: Can we have the sample?
A: Of course, you can place a sample order first to test the company's quality and service. For some products, we can provide free samples.
Q: What is the MOQ (minimum order quantity)?
A: We have a significant advantage in MOQ because we offer small MOQ. 100 bottles of injection and 1kg of powder.
Q: Can I use my own design package?
A: Yes, OEM service is available. We can customize packaging and labels to create a unique brand for dealers. In addition, we can also customize specifications and formulas according to different requirements.
Q: How about delivery time?
A: We have ample inventory and are ready to ship. Most of our factory orders are normally shipped within 3-5 days upon receiving your payment.
Q: Do you provide after sales service?
A: We have a clear division of work and offer after-sales service within 8 hours. If there are any quality problems, we will be responsible to the end.
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